Toups EG, Ugiliweneza B, Howley SP, Neal CJ, Harrop JS, Guest JD, Grossman RG, Fehlings MG. North American Clinical Trials Network for Spinal Cord Injury Registry: Methodology and Analysis. J Neurotrauma. 2023 Sep;40(17-18):1817-1822. doi: 10.1089/neu.2022.0403. PMID: 37125443.

Fehlings MG, Moghaddamjou A, Harrop JS, Stanford R, Ball J, Aarabi B, Freeman BJC, Arnold PM, Guest JD, Kurpad SN, Schuster JM, Nassr A, Schmitt KM, Wilson JR, Brodke DS, Ahmad FU, Yee A, Ray WZ, Brooks NP, Wilson J, Chow DS, Toups EG, Kopjar B. Safety and Efficacy of Riluzole in Acute Spinal Cord Injury Study (RISCIS): A Multi-Center, Randomized, Placebo-Controlled, Double-Blinded Trial. J Neurotrauma. 2023 Sep;40(17-18):1878-1888. doi: 10.1089/neu.2023.0163. Epub 2023 Jul 13. PMID: 37279301; PMCID: PMC10460693.

Fehlings MG, Neal CJ, Hejrati N, Harrop JS, Toups EG, Guest JD. An Introduction to the North American Clinical Trials Network for Spinal Cord Injury Special Edition: Reflections on Accomplishments and a Look to the Future. J Neurotrauma. 2023 Sep;40(17-18):1811-1816. doi: 10.1089/neu.2022.0402. PMID: 37668560.

Tator CH, Guest JD, Neal CJ, Howley SP, Toups EG, Harrop JS, Aarabi B, Shaffrey CI, Fehlings MG. History and Accomplishments of the North American Clinical Trials Network for Spinal Cord Injury, 2004-2022. J Neurotrauma. 2023 Sep;40(17-18):1823-1833. doi: 10.1089/neu.2022.0404. PMID: 36515162.

Futch BG, Kouam RW, Ugiliweneza B, Harrop J, Kurpad S, Foster N, Than K, Crutcher C, Goodwin CR, Tator C, Shaffrey CI, Aarabi B, Fehlings M, Neal CJ, Guest J, Abd-El-Barr MM. Demographics, Mechanism of Injury, and Outcomes for Acute Upper and Lower Cervical Spinal Cord Injuries: An Analysis of 470 Patients in the Prospective, Multi-Center, North American Clinical Trials Network Registry. J Neurotrauma. 2023 Sep;40(17-18):1918-1927. doi: 10.1089/neu.2022.0407. PMID: 36852492.

Kelly-Hedrick M, Ugiliweneza B, Toups EG, Jimsheleishvili G, Kurpad SN, Aarabi B, Harrop JS, Foster N, Goodwin RC, Shaffrey CI, Fehlings MG, Tator CH, Guest JD, Neal CJ, Abd-El-Barr MM, Williamson T. Interhospital Transfer Delays Care for Spinal Cord Injury Patients: A Report from the North American Clinical Trials Network for Spinal Cord Injury. J Neurotrauma. 2023 Sep;40(17-18):1928-1937. doi: 10.1089/neu.2022.0408. PMID: 37014079.

Hejrati N, Aarabi B, Neal CJ, Ugiliweneza B, Kurpad SN, Shaffrey CI, Guest JD, Toups EG, Harrop JS, Fehlings MG. Trends in the Use of Corticosteroids in the Management of Acute Spinal Cord Injury in North American Clinical Trials Network Sites. J Neurotrauma. 2023 Sep;40(17-18):1938-1947. doi: 10.1089/neu.2022.0409. PMID: 36597351.

Jiang F, Jaja BNR, Kurpad SN, Badhiwala JH, Aarabi B, Grossman RG, Harrop JS, Guest JD, Schär RT, Shaffrey CI, Boakye M, Toups EG, Wilson JR, Fehlings MG; North American Clinical Trials Network Collaborators. Acute Adverse Events After Spinal Cord Injury and Their Relationship to Long-term Neurologic and Functional Outcomes: Analysis From the North American Clinical Trials Network for Spinal Cord Injury. Crit Care Med. 2019 Nov;47(11):e854-e862. doi: 10.1097/CCM.0000000000003937. PMID: 31389834.

Wilson JR, Jaja BNR, Kwon BK, Guest JD, Harrop JS, Aarabi B, Shaffrey CI, Badhiwala JH, Toups EG, Grossman RG, Fehlings MG. Natural History, Predictors of Outcome, and Effects of Treatment in Thoracic Spinal Cord Injury: A Multi-Center Cohort Study from the North American Clinical Trials Network. J Neurotrauma. 2018 Nov 1;35(21):2554-2560. doi: 10.1089/neu.2017.5535. Epub 2018 Jun 7. Erratum in: J Neurotrauma. 2020 Mar 15;37(6):906. doi: 10.1089/neu.2017.5535.correx. PMID: 29665733.

Kelly-Hedrik M, Abd-El-Barr MM, Aarabi B, Curt A, Howley SP, Harrop JS, Kirshblum S, Neal CJ, Noonan V, Park C, Ugiliweneza B, Tator C, Toups EG, Fehlings MG, Williamson T, Guest JD. Importance of Prospective Registries and Clinical Research Networks in the Evolution of Spinal Cord Injury Care. J Neurotrauma. 2023 Sep;40(17-18):1834-1848. doi: 10.1089/neu.2022.0450. PMID: 36576020.

Corrrection to: Natural History, Predictors of Outcome, and Effects of Treatment in Thoracic Spinal Cord Injury: A Multi-Center Cohort Study from the North American Clinical Trials Network by Wilson, J.R., Jaja, B.N.R., Kwon, B.K., Guest, J.D., Harrop, J.S., Aarabi, B., Shaffrey, C.I., Badhiwala, J.H., Toups, E.G., Grossman, R.G., and Fehlings, M.G. J. Neurotrauma 2018;35(21):2554-2560. (DOI: 10.1089/neu.2017.5535). J Neurotrauma. 2020 Mar 15;37(6):906. doi: 10.1089/neu.2017.5535.correx. Erratum for: J Neurotrauma. 2018 Nov 1;35(21):2554-2560. doi: 10.1089/neu.2017.5535. PMID: 32155393; PMCID: PMC7075025.

Vedantam A, Ugiliweneza B, Williamson T, Guest JD, Harrop JS, Tator CH, Aarabi BA, Fehlings MG, Kurpad SN, Neal CJ. Evolving Profile of Acute Spinal Cord Injury Demographics, Outcomes, and Surgical Treatment in North America: Analysis of a Prospective Multi-Center Dataset of 989 Patients. J Neurotrauma. 2023 Sep;40(17-18):1948-1958. doi: 10.1089/neu.2022.0410. PMID: 36448585.

Jaja BNR, Jiang F, Badhiwala JH, Schär R, Kurpad S, Grossman RG, Harrop JS, Guest JD, Toups EG, Shaffrey CI, Aarabi B, Boakye M, Fehlings MG, Wilson JR. Association of Pneumonia, Wound Infection, and Sepsis with Clinical Outcomes after Acute Traumatic Spinal Cord Injury. J Neurotrauma. 2019 Nov 1;36(21):3044-3050. doi: 10.1089/neu.2018.6245. Epub 2019 Jun 17. PMID: 31007137; PMCID: PMC6791472.

Jentzsch T, Cadotte DW, Wilson JR, Jiang F, Badhiwala JH, Akbar MA, Rocos B, Grossman RG, Aarabi B, Harrop JS, Fehlings MG. Spinal Cord Signal Change on Magnetic Resonance Imaging May Predict Worse Clinical In- and Outpatient Outcomes in Patients with Spinal Cord Injury: A Prospective Multicenter Study in 459 Patients. J Clin Med. 2021 Oct 18;10(20):4778. doi: 10.3390/jcm10204778. PMID: 34682902; PMCID: PMC8537526.

Neal CJ, Ugiliweneza B, Toups EG, Abd-El-Barr M, Jimsheleishvili G, Kurpad SN, Aarabi B, Harrop JS, Shaffrey CI, Fehlings MG, Tator CH, Grossman RG, Guest JD. Variability in Early Surgery for Acute Cervical Spinal Cord Injury Patients: An Opportunity for Enhanced Care Delivery. J Neurotrauma. 2023 Sep;40(17-18):1907-1917. doi: 10.1089/neu.2022.0507. PMID: 37125447.

Mansoor Ali D, Sivaganesan A, Neal CJ, Thalheimer S, Ugiliweneza B, Toups EG, Abd-El-Barr M, Jimsheleishvili G, Kurpad SN, Aarabi B, Shaffrey CI, Fehlings MG, Tator CH, Grossman RG, Guest JD, Harrop JS. Bulbocavernosus Reflex Has No Prognostic Features During the Acute Evaluation of Spinal Cord Injuries. J Neurotrauma. 2023 Sep;40(17-18):1970-1975. doi: 10.1089/neu.2022.0412. PMID: 36884291.

Furlan JC, Wilson JR, Massicotte EM, Sahgal A, Fehlings MG. Recent advances and new discoveries in the pipeline of the treatment of primary spinal tumors and spinal metastases: a scoping review of registered clinical studies from 2000 to 2020. Neuro Oncol. 2022 Jan 5;24(1):1-13. doi: 10.1093/neuonc/noab214. PMID: 34508647; PMCID: PMC8730766.

Aarabi B, Harrop JS, Tator CH, Alexander M, Dettori JR, Grossman RG, Fehlings MG, Mirvis SE, Shanmuganathan K, Zacherl KM, Burau KD, Frankowski RF, Toups E, Shaffrey CI, Guest JD, Harkema SJ, Habashi NM, Andrews P, Johnson MM, Rosner MK. Predictors of pulmonary complications in blunt traumatic spinal cord injury. J Neurosurg Spine. 2012 Sep;17(1 Suppl):38-45. doi: 10.3171/2012.4.AOSPINE1295. PMID: 22985369.

Wilson JR, Davis AM, Kulkarni AV, Kiss A, Frankowski RF, Grossman RG, Fehlings MG. Defining age-related differences in outcome after traumatic spinal cord injury: analysis of a combined, multicenter dataset. Spine J. 2014 Jul 1;14(7):1192-8. doi: 10.1016/j.spinee.2013.08.005. Epub 2013 Nov 7. PMID: 24210580.

Grossman RG, Fehlings MG, Frankowski RF, Burau KD, Chow DS, Tator C, Teng A, Toups EG, Harrop JS, Aarabi B, Shaffrey CI, Johnson MM, Harkema SJ, Boakye M, Guest JD, Wilson JR. A prospective, multicenter, phase I matched-comparison group trial of safety, pharmacokinetics, and preliminary efficacy of riluzole in patients with traumatic spinal cord injury. J Neurotrauma. 2014 Feb 1;31(3):239-55. doi: 10.1089/neu.2013.2969. Epub 2013 Oct 11. PMID: 23859435; PMCID: PMC3904533.

 Grossman RG, Toups EG, Frankowski RF, Burau KD, Howley S.  North American Clinical Trials Network for the Treatment of Spinal Cord Injury: goals and progress. J Neurosurg: Spine.  Sep:17: -10, 2012. PMID: 22985365, DOI: 10.3171/2012.4.AOSPINE1294

Bizhan A, Harrop JS, Tator CH, Alexander M, Dettori, JR, Grossman RG, Fehlings MG, Mirvis SE, Shanmuganathan K, Zacheri KM, Burau KD, Frankowski RF, Toups E, Shaffrey CI, Guest JD, Harkema SJ, Habashi NM, Andrews P, Johnson MM, Rosner, MK. Predictors of pulmonary  complications in blunt traumatic spinal cord injury.  J Neurosurg: Spine. 2012 Sep;17(1 Suppl):38-45. https://doi.org/10.3171/2012.4.aospine1295.

Guest J, Harrop JS, Aarabi B, Grossman RG, Fawcett JW, Fehlings MG, Tator CH. Optimization of the decision-making process for the selection of therapeutics to undergo clinical testing for spinal cord  injury in the North American Clinical Trials Network. J. Neurosurg: Spine: 2012 Sep;17(1 Suppl):94-101. DOI: https://doi.org/10.3171/2012.5.aospine1289.

 Grossman RG, Frankowski RF, Burau KD, Toups EG, Crommett JW, Johnson MM, Fehlings MG, Tator CH, Shaffrey CI, Harkema SJ, Hodes JE, Aarabi B, Rosner MK, Guest JD, Harrop JS. Incidence and severity of acute complications after spinal cord injury. J Neurosurg: Spine. 2012 Sep; 17 (1Suppl): 119-128. DOI: https://doi.org/10.3171/2012.5.aospine12127 .

Chow DSL, Teng Y, Toups EG, Aarabi B, Harrop JS, Shaffrey CI, Johnson MM, Boakye M, Frankowski RF, Fehlings MG, Grossman RG. Pharmacology of riluzole in acute spinal cord injury. J Neurosurg: Spine. 2012 Sep: 17 (1Suppl): 129 – 140. DOI: https://doi.org/10.3171/2012.5.aospine12112.  

 Fehlings MG, Wilson JR, Frankowski RF, Toups EG, Aarabi, B, Harrop JS, Shaffrey CI, Harkema SJ, Guest JD, Tator CH, Burau KD, Johnson MW, Grossman RG.  Riluzole for the treatment of acute traumatic spinal cord injury: rationale for and design of the NACTN Phase I clinical trial. J Neurosurg: Spine: 2012 Sep: 17 (1 Suppl): 151 – 156. PMID: 22985381 DOI: 10.3171/2012.4.AOSPINE1259

Tator CH, Hashimoto R, Raich A, Norvell D, Fehlings MG, Harrop JS, Guest J, Aarabi B, Grossman RG.  Translational potential of preclinical trials of neuroprotection through pharmacotherapy for spinal cord injury.  J Neurosurg: Spine: 2012 Sep: 17: 157 – 229. PMID: 22985382, DOI: 10.3171/2012.5.AOSPINE12116.

Harrop JS, Hashimoto R, Norvell D, Raich A, Aarabi B, Grossman RG, Guest JD, Tator CH, Chapman J, Fehlings MG.  Evaluation of clinical experience using cell- based therapies in patients with spinal cord injury: a systematic review.  J Neurosurg: Spine: 2012 Sep: 17 (1 Suppl): 230 – 246. PMID: 22985383,DOI: 10.3171/2012.5.AOSPINE12115.

Fehlings MG, Wilson JR. Editorial: Multicenter clinical research networks for traumatic spinal cord injury: a critical pathway to discovery. J Neurosurg: Spine: Sep 17 (1Suppl) :5, 2012. https://doi.org/10.3171/2012.5.AOSPINE12416

Grossman, RG.  Editorial Response.  Multicenter clinical research networks for traumatic spinal cord  injury: a critical pathway to discovery. J Neurosurg: Spine: Sep: 17: 5, 2012.

Grossman RG, Fehlings MG, Frankowski RF, Burau KD, Chow D, Tator CH, Teng Y, Toups EG, Harrop JS, Aarabi B, Shaffrey CI, Johnson MM, Harkema SJ, Boakye M, Guest JD, Wilson JR. A Prospective Multicenter Phase 1 Matched Comparison Group Trial of Safety, Pharmacokinetics, and Preliminary Efficacy of Riluzole in Patients with Traumatic Spinal Cord Injury. J Neurotrauma: Feb. 31:239-255, 2014.  http://online.liebertpub.com/doi/abs/10.1089/neu.2013.2969  

Fehlings MG, Nakashima H, Nagoshi N, Chow DS, Grossman RG, Kopjar B. Rationale, design and critical end points for the Riluzole in Acute Spinal Cord Injury Study (RISCIS): a randomized, double-blinded, placebo-controlled parallel multi-center trial. Spinal Cord. 2016 Jan;54(1):8-15. PMID: 26099215, https://doi.org/10.1038/sc.2015.95.

Sarkar M, Grossman RG, Toups EG, Chow DS. UPLC-MS/MS assay of riluzole in human plasma and cerebrospinal fluid (CSF): Application in samples from spinal cord injured patients. J Pharm Biomed Anal. 2017 Nov 30;146:334-340. doi: 10.1016/j.jpba.2017.08.045. PMID: 28917164  https://doi.org/10.1016/j.jpba.2017.08.045

Szuflita NS, Neal CJ, Rosner MK, Frankowski RF, Grossman RG.   Spine Injuries Sustained by U.S. Military Personnel in Combat are Different From Non-Combat Spine Injuries. Mil Med. 2016 Oct;181(10):1314-1323. PMID: 27753570 DOI: 10.7205/MILMED-D-15-00332

Wilson J, Jaja B, Kwon E, Guest J, Harrop J, Aarabi B, Shaffrey C, Badhiwala J, Toups E, Grossman R, Fehlings M. Natural History, Predictors of Outcome, and Effects of Treatment in Thoracic Spinal Cord Injury: A Multi-Center Cohort Study from the North American Clinical Trials Network J Neurotrauma. 2018 Nov 1;35(21):2554-2560. PMID: 31182786, DOI: 10.1038/s41393-019-0299-8 

 Sarkar M, Grossman R, Toups E, Chow D. Rational Design and Development of a Stable Liquid Formulation of Riluzole and its Pharmacokinetic Evaluation after Oral and IV Administrations in Rats Eur J of Pharm Sci 2018 Dec 1;125:1-10. DOI: 10.1016/j.ejps.2018.09.004. Epub 2018 Sep 8. 

Aimetti A, Kirshblum S, Curt A, Mobley J, Grossman R, Guest J.  Natural History of Neurological Improvement Following Complete (AIS A) Thoracic Spinal Cord Injury Across Available Registries to Guide Acute Clinical Trial Design and Interpretation.  Spinal Cord.2019 Sep;57(9):753-762.  PMCID: PMC6760562, PMID: 31182786, DOI: 10.1038/s41393-019-0299-8 

Ashley Nguyen, Diana S-L Chow, Lei Wu., Yang (Angela) Teng, Mahua Sarkar, Elizabeth G. Toups, James S. Harrop, Karl M. Schmitt, Michele M. Johnson, James D. Guest, Bizhan Aarabi, Christopher I. Shaffrey, Maxwell Boakye, Ralph F. Frankowski, PhD, Michael G. Fehlings, Robert G Grossman. Longitudinal impacts of acute spinal cord injury on clinical pharmacokinetics of riluzole, a potential neuroprotective agent, J Clin Pharmacol. 2021 Apr 28 PMID: 33908635, DOI: 10.1002/ jcph.1876